Radiosensitization Through Targeting Molecular Alterations in Adenoid Cystic Carcinoma
نویسندگان
چکیده
منابع مشابه
Primary cutaneous adenoid cystic carcinoma of shin
Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare variant of adenoid cystic carcinoma (ACC) which originates from the skin adnexa, most probably eccrine and apocrine glands. This tumor has a head and neck predilection and also occurs in the chest, abdomen, back, and perineum. We hereby present a 63-year-old man with PCACC located on the shin. No previous similar case has been reporte...
متن کاملLaryngeal adenoid cystic carcinoma.
Adenoid cystic carcinomas are malignant tumours and occur in the major and the minor salivary glands. Laryngeal adenoid cystic carcinomas are rare and account for less than 1% of all malignant tumours in the larynx. Adenoid cystic carcinoma is characterised by slow progression, multiple recurrences and late distant metastasis. The aetiology of adenoid cystic carcinoma remains unknown. They usua...
متن کاملSuppression of NF-κB activity by mutant IκBα: A molecular target for radiosensitization of adenoid cystic carcinoma
The constitutive activation of the nuclear factor κB (NF-κB) signaling pathway is involved in oncogenesis, invasive growth, metastasis and induced resistance to radiation and chemotherapy. Selective inhibition of the NF-κB signaling pathway, either by a mutant inhibitor or pharmacological agents, improves the therapeutic efficiency of irradiation. In the present study, the changes in NF-κB expr...
متن کاملMale Breast Adenoid Cystic Carcinoma
INTRODUCTION Adenoid cystic carcinoma (ACC) of the breast is a rare condition, and cases in male patients are even less common. CASE We describe a case of ACC of the breast with axillary lymph node metastasis, disseminated osteolytic bone metastasis and bone marrow involvement in a 41-year-old man. CONCLUSION Male breast ACC is an extremely rare malignancy; there can be difficulty in obtain...
متن کاملRevisiting epithelial-to-mesenchymal transition through adenoid cystic carcinoma.
Adenoid cystic carcinoma (ACC) has a 5-year survival rate of 90%. The 15-year survival rate drops to 10% due to recurrence and invasion. ACC has three subtypes: cribriform, tubular, and solid. The cribriform subtype has the best prognosis and the solid subtype has the worst prognosis. By immunohistochemistry of tissue sections, we showed that the solid form expresses αvβ6 integrin and tenascin-...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2018
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2017.12.177